Previous reports have shown that LRPPRC may act as an oncogene in several kinds of cancer, including hepatoma, lung adenocarcinoma, esophageal squamous cell carcinoma, and colon cancer (Tian et al., 2012); however, the exact role of LRPPRC in pancreatic cancer and whether its regulatory effect on mitochondria is involved in these processes are still unclear. Here, LRPPRC is linked to esophageal squamous cell carcinoma.