LRPPRC and neoplasm: As expected, cell cycle blockade in response to LRPPRC knockdown was obviously reversed by the addition of 3-MA (Figure 6C), and the proliferation inhibition in response to LRPPRC knockdown was partially reversed by the addition of 3-MA, indicating that LRPPRC-regulated mitophagy/autophagy is critical for its role as a tumor promoter (Figure 6D).