It was recently reported that in cancer development, LRPPRC associates with mitochondria and thus regulates mitophagy/autophagy (Zou et al., 2014; Zhang et al., 2017), which prompted us to explore whether LRPPRC in pancreatic cancer cells is associated with endogenous cleavage of LC3. This evidence concerns the gene MAP1LC3A and familial pancreatic carcinoma.