It was recently reported that in cancer development, LRPPRC associates with mitochondria and thus regulates mitophagy/autophagy (Zou et al., 2014; Zhang et al., 2017), which prompted us to explore whether LRPPRC in pancreatic cancer cells is associated with endogenous cleavage of LC3. The gene discussed is LRPPRC; the disease is familial pancreatic carcinoma.