FAM86C1 (Family With Sequence Similarity 86 Member C1) and FOLR3 (Folate Receptor Gamma) had been reported for their associations with various weight-related phenotypes such as bone mineral density (Li et al., 2019) and BMI (Hair, 2014; Mrozikiewicz et al., 2019), which closely related to osteoporosis (Li et al., 2019; Mrozikiewicz et al., 2019) and obesity (Gómez-Ambrosi et al., 2004). This evidence concerns the gene FOLR3 and obesity due to melanocortin 4 receptor deficiency.