The TCGA analysis showed an inverse correlation between single SCNA score and CYT across disease stages making plausible to ask “Do tumor cells with experimentally-induced aneuploidy also dysregulate T cells through a cell-nonautonomous mechanism?” This possibility was tested focusing on two key functional parameters, IFNγ and Granzyme B, and their production by human T cells activated by anti-CD3/anti-CD28 antibodies. The gene discussed is CD28; the disease is neoplasm.