In addition, because the critical transcription factor contributes to immune response, the increased NF-κB level with the cooperative expression of TNF-α was detected both in the intestinal and hippocampal zones, which are associated with amnesia; the symptoms of amnesia and colitis were attenuated after the recovery of gut microbiota α-diversity was disturbed in a colitis model (82). The gene discussed is NFKB1; the disease is amnesia.