Multiple immune cells, including T lymphocytes, macrophages, and neutrophils, are abnormally activated and do not only elicit acute colitis but also further damage the colon by upregulating the pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), and IL-6 (Sun et al., 2020). The gene discussed is TNF; the disease is colitis.