Among the 10 hub genes we identified through Cytoscape, the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), a rate-limiting enzyme catalyzing cholesterol production, was decreased in human PCOS granulosa cells and prenatally hyperandrogenized animals (34), which may be caused by the feedback inhibition of elevated androgen levels in PCOS (35). This evidence concerns the gene HMGCR and polycystic ovary syndrome.