AGER and prediabetes syndrome: Even though the underlying mechanism for the downregulation of AGEs-dependent RAGE activation remains to be further elucidated, it is noteworthy to state that the downregulation of AGEs-dependent RAGE activation that occurred at the prediabetic stage is conceivably one of the mechanisms to promote osteoblast differentiation and survival, which then maintains osteogenesis and bone integrity in individuals with prediabetes.