For example, we identified Cyp26b1, a retinoic acid degrading enzyme, as a candidate gene for the frequency of entering the center zone and total distance to the center zone in OFT; both of which are measures of anxiety-like behaviors (rats with more anxiety-like behavior would enter the center zone less frequntly and have smaller distance to the center zone) (11). This evidence concerns the gene CYP26B1 and Anxiety.