TGFB1 and Hepatic fibrosis: Similar to TGF-β1, EVs with highly expressed Lnc-MALAT1 that were derived from the plasma of liver fibrosis patients up-regulated the expression of the fibrotic markers and enhanced the Wnt/β-catenin signaling in HSCs, and blocking of Lnc-MALAT1 expression by Lnc-MALAT1-specific siRNA abolished these effects in both the EVs-treated and TGF-β1-treated HSCs.