Notably, pre-transfection of siRNA specific for Lnc-MALAT1 into the cells inhibited the fibrosis plasma EVs-induced expressions of these molecules (Lane 6, Figures 3A,B), demonstrating that the enhanced effects by the plasma EVs from the liver fibrosis patients were Lnc-MALAT1-depentent. Here, MALAT1 is linked to fibrosis.