RETN and Insulin resistance: It is worth mentioning that bio-products based on Citrus help in glycemic control (Mollace et al., 2011; Ding et al., 2012; Kim et al., 2013; Lu et al., 2013; Raasmaja et al., 2013; Muhtadi et al., 2015; Dinesh and Hegde, 2016; Ashraf et al., 2017; Fayek et al., 2017), possibly by reducing resistin (Kim et al., 2013), an adipocytokine whose increase has been associated with insulin resistance, atherosclerosis, oxidative stress, and inflammation.