Therefore, proteins such as the transcription factor NR4A2 whose suppression has been linked to the gastrointestinal inflammation and adenocarcinoma (Han and Cao, 2012; Mohan et al., 2012; Yeh et al., 2016), and the A20 protein, an NFκB inhibitor (Kuzuhara et al., 2007a) may indicate promising candidates for further analysis on Tipα activity and pathogenesis. The gene discussed is TNFAIP3; the disease is adenocarcinoma.