After respiratory epithelial cells were first infected by virus, virus infection activates pattern recognition receptors in these cells, triggering the production and release of type I and type III interferons (IFNs) and other proinflammatory mediators (such as cytokines, chemokines and antimicrobial peptides), so as to start the host’s innate and acquired immune response, which further activated the secondary cytokines (such as IL-10, IFN-γ, MCP-1, IL-4, and IL-17) and lead to cytokines storm (Vabret et al., 2020). Here, IFNG is linked to viral infectious disease.