Indeed, proinflammatory cytokines, including IL-1beta, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), have been implicated in the etiology of depression, contributing to cellular damage, impaired neuronal plasticity, and neurotransmission in the prefrontal cortex and hippocampus (Felger and Lotrich 2013). The gene discussed is TNF; the disease is major depressive disorder.