In mouse embryonic fibroblasts, p65 and RelB exhibit negative crosstalk (Marienfeld et al., 2003; Jacque et al., 2005) and in mouse kidney fibroblasts, RelB suppresses the production of TNF (Xia et al., 1999), which is a common mediator in CKD (Stenvinkel et al., 2021) (Figure 5). Here, TNF is linked to chronic kidney disease.