AHR-deficient mice develop cardiac hypertrophy through mechanisms involving HIF-1α cell signals (Thackaberry et al., 2002), Ang II-induced fibrosis (Ichihara et al., 2019), increased plasma levels of endothelin-1, and elevated mean arterial pressures (Lund et al., 2003). The gene discussed is AHR; the disease is cardiac hypertrophy.