For example, the sodium-glucose transport protein 2 (SGLT2) inhibitor dapgliflozin was recently approved for progressive non-diabetic kidney disease of many etiologies as a result of studies demonstrating efficacy in reducing the risk for a combined endpoint of kidney function decline, kidney failure, cardiovascular death and hospitalization for heart failure (Wheeler et al., 2021). This evidence concerns the gene SLC5A2 and diabetic kidney disease.