With the help of cancer stem cell–specific targeting and P-gp inhibitor Tar, the accumulation of DOX delivered by the mSiO2-dPG nanocarriers could be greatly increased in the drug-resistant three-dimensional mammosphere of breast cancer stem cells, and the chemotherapeutic efficacy against breast cancer stem cells was enhanced (Pan et al., 2021). This evidence concerns the gene RBM8A and cancer.