A review of 60 cases of ICI-related encephalitis, predominantly in patients with melanoma (38.3%) and non-small cell lung cancer (30.0%), showed an association with onconeural autoantibodies in 21 cases (35.0%), anti-Ma2 being the most commonly found (15%), followed by anti-Hu (8.3%), anti-GAD (5.0%), anti-NMDAR (3.3%), anti-CASPR2 (1.7%), and anti-glial nuclear antibody (AGNA) (1.7%) (Touat et al., 2017b). This evidence concerns the gene PNMA2 and encephalitis.