GRIm-Score presented a strong prognostic indication for patients toward immunotherapies, and its reliability has already been confirmed in several studies for lung cancer patients treated with cytotoxic chemotherapy, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI), or second-line immunotherapy (Minami et al., 2019; Lenci et al., 2021). Here, EGFR is linked to lung cancer.