The optimized HCC-GRIm-Score integrated ALB, LDH, NLR, AST-to-ALT ratio and TBIL indicated that HCC patients treated by ICIs with high scores (HCC-GRIm-Score>2 points) suffered from adverse prognosis, and it also demonstrated superior prognostication performance compared to the Ori-GRIm-Score, TNM staging system and BCLC staging system (AUC, 0.719 vs. 0.700 vs. 0.602 vs. 0.571, respectively). This evidence concerns the gene GPT and hepatocellular carcinoma.