YWHAQ and hyperinsulinemic hypoglycemia, familial, 4: Within the past two decades, several animal models of schizophrenia with 14-3-3 deficiency were established (Cheah et al., 2012; Foote et al., 2015) and provided valuable insight into the functions of 14-3-3 at postsynaptic site and how 14-3-3 deficiency affects synaptic activities.