Our stratified analyses additionally indicate that the deleterious effects of APOE-ε4 and age in prompting a higher regional SUVRs as a function of CSF Aβ42/40 concentrations, is remarkably higher in women compared to men, suggesting that the three risk factors may further interact among each other to exacerbate the emergence and progression of AD pathology. This evidence concerns the gene APOE and Alzheimer disease.