AKI onset was followed by worsening of respiratory function (SaO2 and P/F), increases in markers of hypoxic damage (lactic acid) and cell death (LDH), higher glucose levels and WBC count, decrease in platelet count and worsening of coagulopathy (elongation on PT and APTT), liver-muscle damage (CPK and GGT), and, as expected, increase in creatinine, potassium levels, urine density and proteinuria (Fig. 3 and detailed in Suppl. The gene discussed is PIK3C2A; the disease is acute kidney injury.