Importantly, sustained treatment of 5XFADhomo mice with DA1 peptide restored the plasma concentrations of 24-OHC to levels similar to those measured in WT mice treated with control peptide (Fig. 5i), further supporting a role for ATAD3A oligomerization in inhibiting CYP46A1 in AD mouse brains. This evidence concerns the gene CYP46A1 and Alzheimer disease.