We showed that the immunodensities of Iba1 (a marker of microglia) and GFAP (a marker of astrocytes) were significantly reduced in the cortex of 5XFADhet;CMV;ATAD3Afl/+ mice compared to 5XFADhet;ATAD3A+/+ mice (Fig. 3g), indicating a reduction of AD-associated gliosis. This evidence concerns the gene AIF1 and Alzheimer disease.