Future studies of CYP46A1-overexpression in neurons of ATAD3A heterozygous knockout AD mice will further help to address the impact of neuronal CYP46A1 restoration on the MAM impairment, cholesterol metabolism dysregulation, and AD-associated neuropathology that are mediated by ATAD3A oligomerization. This evidence concerns the gene ATAD3A and Alzheimer disease.