NFKB1 and squamous cell carcinoma: gingivalis induces the expression of B7-H1 and B7-DC receptors on the surface of gingival epithelial cells and squamous cell carcinoma cells.102 And also, P. gingivalis can interact with PAR-2 and PAR-4 to promote their gene expression.97 PAR-2 can activate NF-κB and PAR-4 can promote the phosphorylation of ERK1/2, p38, NF-κB, and thus promote the increase of inactive proMMP9 expression.103P.