gingivalis can also activate the classical signaling pathway-phosphatidylinositol 3-hydroxy kinase (PI3K)/Akt signaling pathway, and activate the expression of NF-κB, participate in a series of processes such as anti-apoptosis, promote angiogenesis and tumor cell invasion, and can further promote anti-apoptosis factor expression.96 In addition, P. gingivalis up-regulates the expression level of miRNA-203, inhibiting the negative regulatory molecule-cytokine signal transfer to suppressor of cytokine signaling-3 (SOCS3) function, thereby inhibiting cell apoptosis.96P. Here, AKT1 is linked to neoplasm.