CRP and periodontitis: Patients with periodontitis have elevated levels of systemic inflammatory mediators, such as c-reactive protein, pentaxin-3, and fibrinogen.172 Under active periodontal treatment intervention, these systemic inflammation biomarkers can be significantly down-regulated.173 Therefore, the disordered oral flora of patients with periodontitis can not only mediate the periodontal inflammatory state but also affect the systemic inflammatory state of the distal body.