IL6 and infection: 143 Periodontal disease-related bacteria can stimulate cells to produce inflammatory factors such as IL-1β, IL-6, TNF-α, and enter the blood circulation from the damaged periodontal tissue, causing related inflammation and promoting the formation of atherosclerotic plaques.144 Animal experiments found that after infection of P. gingivalis in ApoE gene-deficient mouse models, the onset of AS near the aorta and the aortic trunk was earlier and the damage was more serious.145P.