In addition, Bhat et al. found that endotoxin stimulation by P. gingivalis up-regulates the expression of immune-inflammatory response-related genes (Cd8a, Cd14, and Icam1) and insulin signaling pathway-related genes (G6pc and Insl3) of the pancreatic β-cell line MIN6.169 Animal experiments have also confirmed that the dysbacteriosis caused by periodontitis can promote the occurrence of insulin resistance in mice on a high-fat diet through an adaptive immune response. This evidence concerns the gene INS and Insulin resistance.