In favor of the malignant role for TGFβR2, overexpression of TGFβR2 or upregulation of TGFβ signature genes is associated with lung metastasis as well as lower survival in human BLBCs [16, 17], and higher stromal TGFβR2 is associated with poorer prognosis breast cancers [37]. This evidence concerns the gene TGFB1 and breast cancer.