We knocked out Tgfβr2 in p18−/−; Brca1MGKO tumor cells and found that Tgfβr2 KO led to lower expression of the EMT markers Vim, Fn, Snail, Zeb1, Slug, and higher expression of the epithelial markers including Cdh1 and Epcam (Fig. 5A, B). The gene discussed is ZEB1; the disease is neoplasm.