Interestingly, we found that Tgfβr2 mRNA did not elevate in K14-Cre;p53f/f;Brca1f/f mammary tumors, suggesting that upregulation of Tgfβr2 may be unique to Brca1 germline mutant tumors also deficient in p18. The gene discussed is BRCA1; the disease is breast cancer.