BRCA1 and neoplasm: Immunostaining revealed that Tgfβr2 and p-Smad2 were highly expressed in p18−/−; Brca1MGKO tumor cells, and that the expression pattern of Tgfβr2 in p18−/−; Brca1MGKO tumors was similar with the pattern in p18−/−; Brca1+/− tumors (Figs. 1C, E, 2D).