Similarly, our analysis of NEDD4L showed that BM from relapsed/refractory MM patients (RRMM) had decreased NEDD4L expression compared with BM from healthy donors (HD) (Fig. 1G), and the mRNA levels of NEDD4L were higher in new diagnosis MM (NDMM) than RRMM (Fig. 1H). Here, NEDD4L is linked to Miyoshi myopathy.