Consistent with the analysis of tumor vessel area of human NSCLC tissues and tumors developed in WT and Meflin-KO mice (Figs 5B and 6F), the area of vasculature in tumors developed in doxycycline administered-Meflin-TO was significantly larger than that in Meflin-TO mice not administered doxycycline and control mice that lacked the Meflin-Cre allele (Fig S7D). Here, ISLR is linked to non-small cell lung carcinoma.