We recently described a novel CAF subset characterized by the expression of Meflin (also known as ISLR), a glycosylphosphatidylinositol (GPI)-anchored membrane protein, in pancreatic and colorectal cancers (Mizutani et al, 2019; Kobayashi et al, 2021; Takahashi et al, 2021; Ichihara et al, 2022). Here, ISLR is linked to colorectal cancer.