ISLR and neoplasm: The effect of Meflin deficiency on the antitumor effect of mPD-1 antibody was also evaluated using a linear mixed-effect model with restricted maximum likelihood estimates, which showed that the suppressive effect of anti–mPD-1 antibody on tumor growth was significantly weakened by Meflin-KO (P = 0.0041), although Meflin-KO itself did not exhibit altered tumor growth (P = 0.901, Fig 6C).