Lobular breast cancer metastases, in particular, are more frequently sclerotic and less 18F-FDG-avid.24,25 With invasive ductal cancers, no relationship between 18F-FDG uptake in bone metastases and receptor status, including estrogen receptor (ER), Her2 or triple negative breast cancer, has been shown.24 Here, ESR1 is linked to breast cancer.