Brodská et al. observed that FLT3 and NPM1 were associated with PD-L1 upregulation [71, 73]; meanwhile, Williams et al. found that AML blasts with TP53 mutation were more frequently positive for PD‐L1, which was further confirmed by the studies on MDS and sAML patients by Sallman et al. and Zeidan et al. [75, 80, 81]. Here, CD274 is linked to acute myeloid leukemia.