CD274 and myelodysplastic syndrome: Yoyen-Ermis et al. found that pSTAT3 was upregulated in blasts isolated from MDS/AML patients and THP-1 cell lines after IFN-γ exposure; further investigation showed that Stattic, a small-molecule inhibitor of STAT3/STAT1, was efficient in blocking IFN-γ-induced PD-L1 upregulation [65].