Furthermore, as other immune checkpoints (CTLA-4, TIM-3 and CD47) are also co-expressed with PD-1 in MDS/AML, future studies focusing on the interactions between different immune cells and immune checkpoint molecules in MDS/AML are warranted, and designing more reasonable dual or triplet combination therapies may also help. This evidence concerns the gene HAVCR2 and myelodysplastic syndrome.