Furthermore, PD-1/PD-L1 inhibitor are also examined in combination with other immunotherapeutic agents, including LAG-3 inhibitor, (NCT04913922), CTLA-4 inhibitor (NCT02530463), TIM-3 inhibitor (NCT03066648), CD47 inhibitor (NCT03922477), CD-33 and OX-40 inhibitor (NCT03390296), tumor vaccines (NCT03358719) or chemotherapy (NCT04541277, NCT04214249, NCT04722952 and ChiCTR2100045296). The gene discussed is PDCD1; the disease is neoplasm.