GLA and Fabry disease: FD (Online Mendelian Inheritance in Man [OMIM] #301500), is a progressive X-linked lysosomal storage disorder, caused by deficiency of lysosomal enzyme α-Gal A (Enzyme Commission [EC] number 3.2.1.22) due to pathogenic variants in the encoding GLA gene (OMIM #300644; HGNC 4296) [1, 2, 4, 18].