STAT1 and mastocytosis: Moreover, histological evidence revealed that the infiltration of mast cells through stem cell factor (SCF) can drive STAT1 activation, creating an inflammatory microenvironment in neurofibroma that is considered a clinicopathological hallmark [37, 38]; on the other hand, the increase of mast cells, also known as mastocytosis, is as well critically involved in the pathogenesis of periodontitis through secreting inflammatory cytokines and participating in periodontal tissue destruction [39].