CD274 and neoplasm: The animals treated with KO, KO combined with 1⁄2 dose of oxaliplatin, and a full dose of oxaliplatin showed a significant reduction of PD-L1 expression in tumours by 57.7% (P < 0.001), 46.7% (P < 0.01), and 35.3% (P < 0.05), respectively, compared to the sham group (Fig. 5A, C) There were no significant differences in the expression of PD-L1 between animals received treatments with KO, KO combined with 1⁄2 dose of oxaliplatin, and a full dose of oxaliplatin (P > 0.05).