Another CML cell line, LAMA84, generates EVs that have effects on the human vascular endothelial cells leading to ICAM-1, VCAM‐1, and IL‐8 expression upregulation which indeed shift the tumor microenvironment (TME) to a pro-angiogenic pattern and therefore unfavorable prognosis [104]. This evidence concerns the gene CXCL8 and chronic myelogenous leukemia, BCR-ABL1 positive.