Another in vitro study clarify that exosomes from AML cell lines HEL 92.1.7, HL-60, MOLM-14, and U937 transfer mRNA of insulin-like growth factor 1 receptor (IGF1R), matrix metalloproteinase 9 (MMP-9), nuclear matrix protein 1 (NPM1), CXCR4, and internal tandem duplication mutations in FLT3 (FLT3-ITD) into BM-MSC [71]. The gene discussed is IGF1R; the disease is acute myeloid leukemia.