This amplification region contains 66 genes (Supplementary Table S2), including PPP2R1A. PPP2R1A is known AD risk factor [244] and dephosphorylates tau protein [245, 246]. The script for this CNV analysis can be found in the companion GitHub repository (see the section "Availability of data and software code" for details). Here, PPP2R1A is linked to Alzheimer disease.