Notably, TNBC presenting high TILs may have upregulated PD-L1 expression [32], and conversely, its decrease induced by OTUB1 ablation can reduce its protein binding to the tumor cell surface, facilitate more CD8 T cell infiltration and increase the serum level of interferon-γ to enhance anti-tumor immunity in mice [33]. The gene discussed is OTUB1; the disease is neoplasm.