RARRES2 and Other metabolic disease: Chemerin, also called retinoic acid receptor responder 2 (RARRES2) or tazarotene inducible gene 2 (TIG2), is a novel 14 kDa chemotactic protein that was initially found in psoriasis and later defined as a novel adipokine that is widely present in the liver and adipose tissue and closely related to multiple physiological activities, such as innate immunity, inflammation, endothelial dysfunction, metabolic disorders, and angiogenesis [12–15].