Equally interesting, there was no evident association between specific liver tissue lesions and chemerin levels in patients with MAFLD: moderate to severe steatosis and mild steatosis (SMD: 0.55; 95% CI: -0.59, 1.69; P = 0.344; Fig. 3A), present liver fibrosis and absent liver fibrosis (SMD: 0.66; 95% CI: -0.42, 1.74; P = 0.233; Fig. 3B), present lobular inflammation and absent lobular inflammation (SMD: 0.45; 95% CI: -0.53, 1.42; P = 0.368; Fig. 3C), and present portal inflammation and absent portal inflammation (SMD: 1.92; 95% CI: -0.85, 4.69; P = 0.175; Fig. 3D). The gene discussed is RARRES2; the disease is Hepatic fibrosis.