According to the criterion of degree ≥2 (median degree), betweenness ≥0.0062 (average betweenness), closeness ≥0.3774 (average closeness), and edge count ≥2 (median edge count), six targets, including BCHE, SRD5A2, EPHX2, ADH1C, ADH1A, and CDK1, were identified as potential hub targets of CKI in the treatment of HCC. Here, CDK1 is linked to hepatocellular carcinoma.