Using whole-exome and transcriptome sequencing of tumors from a cohort of 1001 newly diagnosed patients with DLBCL, Reddy et al developed a prognostic model comprising genetic alterations, COO DLBCL subtype, International Prognostic Index (IPI) score and dual MYC and BCL2 expression, that outperformed molecular or clinical factors alone (COO, MYC/BCL2 expression, IPI) in terms of prognostic ability for overall survival (OS) [16]. Here, BCL2 is linked to diffuse large B-cell lymphoma.