To provide a quantitative approach by which clinicians could predict probability of survival in HCC patients, we developed a nomogram by integrating of this novel prognostic signature and clinicopathological characteristics, including age, albumin, total bilirubin, prothrombin time, Child_Pugh classification, histologic grade, TNM stage and liver cirrhosis (Fig. 7a). Here, ALB is linked to hepatocellular carcinoma.