We found that persistent liver-specific ectopic expression of LOX-1 could not only recognize, bind to, and phagocytose circulating Ox-LDL but also inhibit atherosclerosis progression by upregulating the expression of the cholesterol transporters ABCG5 and ABCG8 to excrete cholesterol into the intestinal lumen as bile acids (Patel et al. 2018), thereby enabling Ox-LDL degradation and avoiding Ox-LDL deposition in the vascular wall and lipid-driven inflammatory responses. Here, ABCG8 is linked to atherosclerosis.