AKT1 and brain ischemia: Resveratrol can also increase the expression of the reduced form of Parkinson protein [7], activate the PI3K/Akt/glycogen synthase kinase 3β signaling pathway, elevate the levels of glutathione and SOD, and reduce the level of inducible nitric oxide synthase, thereby inhibiting ROS generation and reducing cerebral ischemia–reperfusion injury [50].