Reversal of WD to CD resulted in a shift from predominant CD8+ > CD4+ pattern to an equilibrium CD8+ = CD4+ pattern in male and sustained predominant CD8+ > CD4+ pattern in females, though both males and females showed significantly decreasing trends for CD8+ T cells (Figure 4G; ***p < 0.0001 and *p = 0.01). Here, CD4 is linked to Wilson disease.