However, during tumor development at 40 weeks of being on a WD, the ratio of the hepatic CD4+ and CD8+ T cells to MDSC significantly decreased in males, while females only decreased the CD4+ T cells/MDSC ratio, with the CD4+ T cells/MDSC ratio lowering below a 1:1 ratio in males and females (Figure 4F, lower panels). This evidence concerns the gene CD8A and neoplasm.