To this end, we took a perturbation three-dimensional approach (Paus, 2005) and demonstrated that the pattern of the immune response reflecting the ratio and proportion of CD4+/CD8+ T cells, Th1/Th2/Th17 cells, NKT/NK cells, M1/M2 macrophages, and T cell phenotypes as well as an acute versus chronic pattern of inflammation are better indicators for understanding how NAFLD-associated HCC is promoted or inhibited. This evidence concerns the gene CD4 and hepatocellular carcinoma.