In regards to CD4+ T cells, while some reports suggest that Th17 cells play no role in liver injury and inhibit HCC (Xie et al., 2010; Zenewicz et al., 2007), other reports show that Th17 cells promote liver injury and HCC (Ma et al., 2020; Nagata et al., 2008). The gene discussed is CD4; the disease is hepatocellular carcinoma.