Finally, there was a signature related to neurodegenerative diseases characterized by neuritic plaques and neurofibrillary tangles, specifically through a study of the role of TAF15 in amyotrophic lateral sclerosis (ALS) and the Alzheimer disease-presenilin pathway from PANTHER (Kapeli et al., 2016). The gene discussed is TAF15; the disease is amyotrophic lateral sclerosis.