Table 2 presents gene burden test results for PLIN1 PTVs in lipodystrophy-related traits available in the UK Biobank. Individuals with PLIN1 PTVs had increased HDL cholesterol (0.12 mmol/L; 95% CI, 0.09 to 0.14, P = 2 × 10–18), increased APOA1 (0.07 g/L; 95% CI, 0.05 to 0.09, P = 5 × 10–12), reduced triglycerides (–0.22 mmol/L; 95% CI, –0.29 to –0.14, P = 3 × 10–11), and reduced diastolic (–0.87 mm Hg; 95% CI, –1.81 to –0.08, P = .06) and systolic blood pressure (–1.67 mm Hg; 95% CI, –3.25 to –0.09, P = .05), and reduced waist-to-hip ratio (–0.02; 95% CI, –0.02 to –0.01, P = 5 × 10–12). The gene discussed is APOA1; the disease is lipodystrophy.