ACE and cancer: There was a single trial with cumulative exposure >3 years, where there was ACE-inhibitor treatment in both study arms (i.e. ONTARGET trial, new cancer occurrence 8.4% with ARB+ACE-inhibitor vs. 7.5% ACE-inhibitor only, RR 1.11 [95% CI 1.00 to 1.23], p = 0.05) (Fig 3, Panel A).