In the subgroup of patients where there was universal background ACE-inhibitor use in both arms, again there was evidence of a significant relationship between cumulative-exposure to ARBs and risk of cancer; (slope = 0.10 [95% CI 0.03 to 0.18], z = 2.76, p = 0.006 with the fixed effect regression method) (Fig 1, Panel B). Here, ACE is linked to cancer.