On the other hand, it should be noted that while the allied class of ACE-inhibitors was associated with an increase in lung cancer in one retrospective cohort study with possible residual confounding [55], ACE-inhibitors had no effect on incident cancer in long-term randomized controlled trials including more than 60.000 patients (RR 1.01 [95% CI 0.95 to 1.07]) [56]. This evidence concerns the gene ACE and lung cancer.