CASC19 and colonic neoplasm: We worked with the National Cancer Institute (NCI) Genome Modification Core facility to introduce the cytomegalovirus (CMV) promoter–driven PCAT2 transgene array (file S1) to the 4q31 locus of SW480 cells using CRISPR and established a stable cell line (SW480PCAT2-KI colon cancer cells) (Fig. 5B and fig.