AlphaB-crystallin (CRYAB, HSPB5) and HSP27 are both members of the small heat shock protein family (Kappé et al. 2010) and each are implicated in the progression of breast cancer (Caporossi et al. 2021; Choi et al. 2019; Wang et al. 2020). The gene discussed is CRYAB; the disease is breast cancer.