Our results are consistent with previous studies that demonstrate high HSP27 expression is linked to ER and PR expression and high CRYAB is linked to basal and triple negative breast cancer (TNBC; ER-/ PR−/HER2−; (Buttacavoli et al. 2021; Parker et al. 2009; Zoppino et al. 2018)). This evidence concerns the gene ESR1 and triple-negative breast carcinoma.