It could be proposed that the antitumor effect of Atr-I in Siha cells would be associated with purinergic P2X7 receptors and its downstream pathway (PI3K/Akt/GSK-3β, AKT, AMPK-PRAS-40-mTOR, NOD-like receptor containing a pyrin inflammasome, etc.)which is regarded as the underlying mechanism of P2X7 receptors in cancers [36–39]. Here, MEFV is linked to cancer.