Recently, a growing body of evidence has demonstrated that the cGAS-STING system plays a central role in numerous diseases such as obesity, nonalcoholic fatty liver disease (NAFLD), and acute kidney injury (Bai et al. 2017; Luo et al. 2018; Maekawa et al. 2019). This evidence concerns the gene CGAS and metabolic dysfunction-associated steatotic liver disease.