In their systematic review of biliary MINEN, Wen et al. reported that incomplete resection, Ki-67 index (≥ 50), tumor stage, NEC grade, and non-NEC grade were prognostic factors for poor overall survival, and that adjuvant chemoradiotherapy for those patients may contribute to better overall survival [8]. The gene discussed is MKI67; the disease is neuroendocrine carcinoma.