PLCE1 has been identified as a locus associated with hypertension (13), descending thoracic aneurysm (14) and with stroke in the dbGAP Gene-Trait Associations dataset (http://amp.pharm.mssm.edu/Harmonizome/gene_set/Stroke/dbGAP+Gene-Trait+Associations). This evidence concerns the gene PLCE1 and hypertensive disorder.