MAP2K7 and melanoma: Indeed, a study investigating the immediate changes in gene expression upon MEK inhibition within melanoma cell lines with hyperactive MAPK signaling, identified several members of the dual specificity phosphatase (DUSP), sprouty RTK-signaling antagonist (SPROUTY; Box 1) and sprouty-related EVH1 domain containing (SPRED) families, namely DUSP4, DUSP6, SPRY2, SPRY4 and SPRED2, as drastically downregulated (Pratilas et al., 2009) (Fig. 2A).