A genomic classification of cutaneous melanoma was proposed on the basis of these observations, upon the release of sequencing data from hundreds of human melanoma samples by The Cancer Genome Atlas (TCGA) consortium, and four groups were thus defined, i.e. BRAF-mutant, NRAS-mutant, NF1-mutant, and triple wild-type (WT) group (Akbani et al., 2015). The gene discussed is NF1; the disease is melanoma.